Using human genetics and genomics to systematically identify and prioritise drug targets.
Website · Platform · Documentation · Community · Blog
Open Targets is a pre-competitive partnership between academic institutes and pharmaceutical companies that helps researchers choose the right drug targets.
We combine large-scale genomic experiments with new computational methods, and we release the data, code and tools we build openly, so that anyone can use them.
Our partners are EMBL-EBI, the Wellcome Sanger Institute, Genentech, GSK, MSD, Pfizer and Sanofi.
The Open Targets Platform is a free resource that brings together public data on targets, diseases, drugs, variants and GWAS studies, and scores the evidence linking each target to each disease. It is updated quarterly.
| I want to… | Go to |
|---|---|
| Explore evidence in the browser | platform.opentargets.org |
| Query programmatically | GraphQL API · playground |
| Analyse everything at scale | Bulk downloads in Parquet via FTP, AWS S3 or Google Cloud Storage · BigQuery |
| Connect an AI assistant | MCP server, hosted at https://mcp.platform.opentargets.org/mcp |
| Understand the data | Documentation · Release notes |
The Platform
platform-webapp: the Platform web application (TypeScript, React)platform-api: the GraphQL API behind the web app (Scala)pipeline: generates each Open Targets data release (Python, PySpark, Polars)platform-deployment-standalone: run your own copy of the Platform locallyplatform-snapshots: software versions behind every release
Genetics, clinical data and data science
gentropy: Python framework for post-GWAS analysis, including fine-mapping, colocalisation and locus-to-gene (docs)mira: harmonises clinical trials, regulatory approvals, drug indications and safety evidence into traceable clinical reports (docs)OnToma: maps disease and phenotype terms to ontologiesotter: lightweight task runner used across our pipelines
AI and agents
platform-mcp: official Model Context Protocol server for the Platform
Our stack: Python · PySpark · Scala · TypeScript · Rust · Nextflow · Google Cloud · Kubernetes
- 💬 Ask a question or share an idea on the Community forum, the best place to reach the team.
- 🐛 Found a bug in the Platform? Open an issue in
opentargets/issues. - 💡 Want a new feature? Post it under Feature requests.
- 🛠️ Contributing code? Pull requests are welcome, and each repository's README explains how to get started.
- 📄 Using our data? Please cite the Platform.
- 🧑💻 Join the team: see current vacancies.
