diff --git a/Lib/test/test_marshal.py b/Lib/test/test_marshal.py
index 449704d1c347b6..5b4d02c232f4a6 100644
--- a/Lib/test/test_marshal.py
+++ b/Lib/test/test_marshal.py
@@ -605,6 +605,30 @@ def test_error_in_set_item(self):
         with self.assertRaisesRegex(TypeError, "'<' not supported"):
             marshal.dumps({complex(nan, 0), complex(nan, 0)})
 
+    def test_set_changed_size(self):
+        # A set is modified while its items are being marshalled.
+        class Item:
+            def __hash__(self):
+                return 0
+            def __buffer__(self, flags):
+                change(sample)
+                return memoryview(b'abc')
+        def grow(sample):
+            sample.update(range(1000, 1400))
+        def shrink(sample):
+            sample.difference_update(range(1, 60))
+        for change in grow, shrink:
+            for version in range(marshal.version + 1):
+                with self.subTest(change=change.__name__, version=version):
+                    # The first item of the set modifies it.
+                    sample = {Item()}
+                    sample.update(range(1, 60))
+                    self.assertIsInstance(next(iter(sample)), Item)
+                    with self.assertRaisesRegex(RuntimeError,
+                                                "set changed size"):
+                        marshal.dumps(sample, version)
+
+
     def test_error_in_buffer(self):
         # The BufferError raised for a non-contiguous buffer is not replaced
         # with a generic error.
diff --git a/Misc/NEWS.d/next/Library/2026-10-11-08-40-00.gh-issue-159185.Sq7cZd.rst b/Misc/NEWS.d/next/Library/2026-10-11-08-40-00.gh-issue-159185.Sq7cZd.rst
new file mode 100644
index 00000000000000..493cd78d6cf015
--- /dev/null
+++ b/Misc/NEWS.d/next/Library/2026-10-11-08-40-00.gh-issue-159185.Sq7cZd.rst
@@ -0,0 +1,4 @@
+Fix a crash in :func:`marshal.dumps` and :func:`marshal.dump` when a set is
+modified while its elements are serialized, for example by the
+:meth:`~object.__buffer__` method of one of its elements.
+:exc:`RuntimeError` is now raised.
diff --git a/Python/marshal.c b/Python/marshal.c
index 6aa99bb4693117..b6a50627854eaf 100644
--- a/Python/marshal.c
+++ b/Python/marshal.c
@@ -681,9 +681,19 @@ w_complex_object(PyObject *v, char flag, WFILE *p)
             p->error = true;
             return;
         }
+        // Marshalling an element can run arbitrary code (an audit hook, or
+        // the __buffer__() method of the element), which can add elements
+        // to the set or remove some: n is not trusted to still be the size
+        // of the set.
         Py_ssize_t i = 0;
+        bool changed = false;
         Py_BEGIN_CRITICAL_SECTION(v);
         while (_PySet_NextEntryRef(v, &pos, &value, &hash)) {
+            if (i == n) {
+                changed = true;
+                Py_DECREF(value);
+                break;
+            }
             PyObject *dump = _PyMarshal_WriteObjectToString(value,
                                     p->version, p->allow_code);
             if (dump == NULL) {
@@ -699,11 +709,15 @@ w_complex_object(PyObject *v, char flag, WFILE *p)
             PyList_SET_ITEM(pairs, i++, pair);
         }
         Py_END_CRITICAL_SECTION();
+        if (!p->error && (changed || i != n)) {
+            PyErr_SetString(PyExc_RuntimeError,
+                            "set changed size during iteration");
+            p->error = true;
+        }
         if (p->error) {
             Py_DECREF(pairs);
             return;
         }
-        assert(i == n);
         if (PyList_Sort(pairs)) {
             p->error = true;
             Py_DECREF(pairs);