diff --git a/Misc/NEWS.d/next/Core_and_Builtins/2026-09-30-21-29-54.gh-issue-158529.kZO7mX.rst b/Misc/NEWS.d/next/Core_and_Builtins/2026-09-30-21-29-54.gh-issue-158529.kZO7mX.rst
new file mode 100644
index 000000000000000..712f26f6493877c
--- /dev/null
+++ b/Misc/NEWS.d/next/Core_and_Builtins/2026-09-30-21-29-54.gh-issue-158529.kZO7mX.rst
@@ -0,0 +1,2 @@
+Fixed crash on Android x86_64, API levels 27-28, caused by mimalloc calling
+system calls directly.
diff --git a/Objects/mimalloc/prim/unix/prim.c b/Objects/mimalloc/prim/unix/prim.c
index 6f78eb72789e8e5..2ee49868a00d503 100644
--- a/Objects/mimalloc/prim/unix/prim.c
+++ b/Objects/mimalloc/prim/unix/prim.c
@@ -60,9 +60,12 @@ terms of the MIT license. A copy of the license can be found in the file
 // Use syscalls for some primitives to allow for libraries that override open/read/close etc.
 // and do allocation themselves; using syscalls prevents recursion when mimalloc is
 // still initializing (issue #713)
+//
+// This isn't done on Android because some versions have an excessively strict
+// seccomp filter (https://github.com/android/ndk/issues/1298).
 //------------------------------------------------------------------------------------
 
-#if defined(MI_HAS_SYSCALL_H) && defined(SYS_open) && defined(SYS_close) && defined(SYS_read) && defined(SYS_access)
+#if defined(MI_HAS_SYSCALL_H) && defined(SYS_open) && defined(SYS_close) && defined(SYS_read) && defined(SYS_access) && !defined(__ANDROID__)
 
 static int mi_prim_open(const char* fpath, int open_flags) {
   return syscall(SYS_open,fpath,open_flags,0);